GLP-1 is an incretin hormone secreted by intestinal cells in response to nutrient intake. It stimulates insulin secretion and inhibits glucagon release, aiding in glucose control. GLP-1 also slows gastric emptying, reduces food intake, and enhances satiety. Pharmaceutical GLP-1 receptor agonists are used in managing type 2 diabetes and obesity, providing glycemic control and promoting weight loss through improved insulin sensitivity and appetite suppression.

This dual agonist targets both GLP-1 and GIP receptors to boost insulin release, reduce glucagon levels, and improve postprandial glucose handling. This peptide is promising in treating obesity and type 2 diabetes, promoting better glycemic control and enhanced fat metabolism.

Ipamorelin: A selective GH secretagogue, Ipamorelin mimics ghrelin, enhancing GH release without increasing cortisol or prolactin levels. It’s often paired with Tesamorelin to boost GH levels more effectively, aiding in muscle growth, fat loss, and improved recovery.

This triagonist (Triple G) peptide acts on the receptors of GLP-1, GIP (Gastric Inhibitory Polypeptide), and glucagon. It enhances insulin secretion, improves glycemic control, and increases energy expenditure by promoting fat oxidation. It is effective in weight loss and improving metabolic disorders, such as type 2 diabetes, by modulating multiple pathways involved in glucose and fat metabolism. That ‘Triple G’ action seems to have more potent effects on a person’s appetite and satisfaction with food. This is a superior choice for those who haven’t had great success with the above peptides.

The ultimate mitochondria boost! Also helps to improve metabolic health. It enhances insulin sensitivity, promotes glucose uptake in muscle cells, and increases fat metabolism. By improving mitochondrial function, MOTS-C plays a role in optimizing energy production, reducing oxidative stress, and protecting against metabolic diseases like obesity, type 2 diabetes, and age-related metabolic decline.

This peptide helps to decrease oxidative stress, decreasing inflammation and improving mitochondrial health. It works as an anti-aging peptide and can be helpful in neurodegenerative diseases, heart failure, or mitochondrial myopathies.

Tesamorelin is a synthetic analog of GHRH, stimulating the pituitary gland to release growth hormone (GH). This leads to increased levels of IGF-1, promoting fat loss (especially visceral fat), muscle growth, and improved metabolic function. Tesamorelin is FDA-approved for reducing abdominal fat in HIV patients with lipodystrophy but also shows potential for anti-aging and fat loss in other populations.

Technically not a true peptide but often referred to as a peptide-like compound, this synthetic molecule blocks a key enzyme that degrades NAD+ which may improve fat loss, and insulin signalling in some clients. Reported benefits seen in studies show normalized blood sugar, decreased dangerous “white fat”independent of diet. Improving energy levels and supporting a weight losing gut microbial population are additional benefits observed.